Recent Discoveries in Autodigestion
Autodigestion in Patients
- Patients in Septic Shock degrade their proteins and generate numerous peptides. A high abundance of peptides in plasma predicts death.
- The first time in medical history the life of a severely injured septic patient could be saved by deliberate blockade of the digestive enzymes.
The Multifaceted Consequences of Autodigestion in Shock and Sepsis
- Autodigestion by Pancreatic Digestive Enzymes Leads to Death. Blockade of Pancreatic Digestive Enzymes in the Intestine Reduces Mortality in Shock.
- Acute Insulin Resistance in Shock is due to Cleavage of the Insulin Receptor by Digestive Enzymes.
- Vasopressure Drug Resistance in Shock is due to Adrenergic Receptor Cleavage by Digestive Enzymes.
- The Repulsive Odor in the Breath during Shock is due to Autodigestion.
- Mucin as a Barrier for Pancreatic Digestive Enzymes - As this barrier is breached you may be digested by your own pancreatic enzymes.
Peptide Generation in Plasma of Septic Patients Predict Death
An independent confirmation of the Autodigestion Hypothesis
Septic shock patients that survide (S) have much lower abundance of cleaved peptides in plasma compared to non-surviving patients (NS) at the time of admission to the intensive care unit (Time T1), and especially 48 hours afterwards (T2). See Bauza-Martinez, Aletti et al..