Erik Kistler


Erik Bruce Kistler, M.D., Ph.D.

Associate Professor

Department of Anesthesiology and Critical Care,

University of California, San Diego

and

Veterans Affairs San Diego Healthcare System,

San Diego, CA 92093, USA

ekistler@ucsd.edu

EDUCATION:

• Doctor of Medicine Degree; George Washington University School of Medicine and Health Sciences, (2003)

• Doctor of Philosophy Degree in Bioengineering; Dissertation: Humoral Mechanisms of Cellular Activation in Ischemic Shock; University of California, San Diego (1998)

• Master of Science Degree in Bioengineering, emphasis on Microcirculation, Numerical Analysis; University of California, San Diego (1994)

• Master of Science Degree in Electrical Engineering, emphasis on Control Systems; University of California, Santa Barbara (1991)

• Bachelor of Science Degree in Electrical/Computer Engineering; University of California, Santa Barbara (1987)

• Bachelor of Arts Degree in Music, Piano; University of California, Santa Barbara (1987)

CONTINUING EDUCATION:

• “Point of Care Ultrasound (POCUS)” Veteran’s Affairs Training Center (2017)

• “Transesophageal Echocardiography course”, Society of Critical Care Medicine (2015)

• “Writing as if your academic life depended on it” course; UCSD Clinical and Translational Research Institute (CITRI) (2013)

• Clinical Research Certification; National Center of Leadership in Academic Medicine (NCLAM), University of California, San Diego (2012)

• Clinical Research Certification; Clinical Research Enhancement through Supplemental Training (CREST), University of California, San Diego (2011)

EXPERIENCE:

09/2017–present VASD Health Care System

Department of Anesthesiology and Critical Care Medicine

Director of Surgical ICU

Staff Physician

07/2014–present University of California, San Diego/VASD Health Care System

Department of Anesthesiology and Critical Care Medicine

Associate Professor Clinical X Series

09/2008–06/2014 University of California, San Diego/VASD Health Care System

Department of Anesthesiology and Critical Care Medicine

Assistant Professor Clinical X Series

07/2014–present University of California, San Diego

Department of Bioengineering

Affiliate Professor

08/2007 – 08/2008 Massachusetts General Hospital

Department of Anesthesiology, Division of Critical Care

Fellow

07/2004 – 06/2007 University of California, San Diego

Department of Anesthesiology

Resident Physician

07/2003 - 07/2004 Harbor Medical Center/University of California, Los Angeles

Department of Surgery

Resident Physician (Intern)

07/2003–present University of California, San Diego

Department of Bioengineering

Academic Researcher

Continuation with research interests in shock and low-molecular weight chemoattractants; advisor and mentor to graduate students.

05/2001 - 07/2001 The Scripps Research Institute/UC San Diego

06/2000 - 08/2000 Departments of Immunology and Bioengineering

04/1998 - 08/1999 Postdoctoral Fellow/Visiting Scholar

Characterization and identification of low-molecular weight tissue factors and humeral activators occurring in SAO (splanchnic arterial occlusion) shock. Analysis performed using techniques such as RP-HPLC, FPLC, and mass spectrometry (MALDI, electrospray, nanospray, including LC-MS). Conducted in vivoshock experiments (rat model) using intravital fluorescent microscopy.

09/1993 - 03/1998 University of California, San Diego

Department of Bioengineering

Microcirculation Laboratory

Graduate Student Researcher

Bioengineering research on novel in vivo fluorescent probes and intravital microscopy as pertains to ischemia/reperfusion injury in the microcirculation and leukocyte activation (e.g.as defined by pseudopod formation, NBT superoxide, chemiluminescence tests, etc). Characterization of neutrophil activators from visceral tissue and occurring in SAO (splanchnic arterial occlusion) and hemorrhagic shock.

03/1993 – 03/1995 The Gulbransen Company

San Diego, CA

Responsible for inputting (through a keyboard interface) every church hymn from every established Christian denomination for uploading of a digital hymnal.

02/1992 - 01/1993 ORINCON Corporation

9363 Towne Centre Drive, La Jolla, CA 93036

Project Leader (Engineer)

Development of novel non-invasive medical diagnostic techniques and use of low-cost monitoring devices and advanced signal processing techniques, including artificial neural networks. Projects included diagnostic techniques for detecting carotid arterial stenosis and ECG waveform identification. Awarded a Small Business Innovative Research Phase I Grant (SBIR) ($50,000) from the National Institutes of Health (NIH) for novel electrophoresis protein identification techniques. A Phase II SBIR Grant was subsequently awarded ($300,000).

06/1991 - 09/1991 Aerospatiale

Etablissement des Mureaux

Division Systèmes Stratégiques et Spatiaux

BP2 78133 Les Mureaux Cedex, Les Mureaux, France

Design Engineer

Involved with H-Infinity research and characterization of analog-to-digital control systems for the Ariane V rocket (Eurospace).

09/1990 - 06/1991 Hughes Aircraft Company

Radar Systems Group

Advanced Systems Division

7200 Hughes Terrace, Los Angeles, CA 90045-0066

Member of Technical Staff

Development of airborne air-to-air search radars for the F-18A/F and B-2 military aircraft. Duties included testing and modification of proposed radar enhancement algorithms. Other duties included air search-and-hold (air-to-air search while targeting) simulations.

Medical License:State of California, State of Massachusetts, DEA certificate, ACLS/BLS, ATLS certifications. Board Certification in: Anesthesiology, Critical Care Medicine

Awards:

Young Investigator Award – Microcirculatory Society (2010)

Glew Award for Research, George Washington University (2000)

Walter Freeman Award (for best paper based on original investigation) (2003)

NIH Young Scientist Training Grant (1992)

UCSB Music Affiliates Scholarship (1987)

US Borax Corporate Scholarship (1982)

Research Support

Ongoing Support

W81XWH-17-2-0047

Kistler (PI) 10/01/17-09/30/20

Role: PI

Noninvasive Enteral Protease Inhibition for the Protection Against Multiorgan Failure and Death in Experimental Trauma-Hemorrhagic Shock

The aim of this project is to develop a minimally invasive method for prolonging life and reversing the shock process in an experimental model of trauma/hemorrhagic shock with and without traumatic brain injury

UC CAI Technical Innovation Grant

Xu (PI) 10/01/18-09/30/20

Role: Co-investigator

Wearable Ultrasound Sensors for the Monitoring of Patients With Peripheral Vascular Disease

The aim of this project is to develop a wearable ultrasound “bandage” that continuously, non-invasively, and accurately measures vascular perfusion to the lower extremities in patients with peripheral vascular disease at risk for limb ischemia

Completed

5 R01 GM085072-06

Schmid-Schönbein (PI) 12/01/13-11/31/17

Role: Co-investigator

Digestive Enzymes and Microvascular Inflammation in Shock

The aim of this project is to elucidate mechanisms and develop new approaches that prevent gut-derived digestive enzymes and systemic degrading proteases from mediating multiorgan system failure

Veteran’s Administration (VA) Career Development Award

Kistler (PI) 04/01/2012-3/31/17

Role: PI

The aim of this project is to identify novel inflammatory mediators responsible for organ failure and death in a rat model of splanchnic arterial occlusion shock, as well as novel treatment strategies to combat this.

Foundation for Anesthesia Education and Research and the American Society of Critical Care Anesthesiologists

Kistler (PI) 07/01/10-06/30/12

Role: PI

A Novel Strategy for the Identification and Treatment of Gut-Derived Inflammatory Mediators Responsible for the Pathogenesis of Circulatory Shock

The aim of this project is to determine new strategies for the identification of inflammatory mediators responsible for organ failure and death in a rat model of hemorrhagic shock, as well as novel treatment strategies to combat this.

V130788 VMRF/VA Clinical Trial (Unrestricted grant from Leading Biosciences)

Kistler (PI) 4/1/2011-06/01/2013

Role: PI

Single Dose Enteral Tranexamic Acid for the Reduction of Morbidity in Hospitalized Critically Ill Patients

The aim of this double-blinded, placebo-controlled interventional study is to determine the efficacy of enteral tranexamic acid on outcomes in critically ill patients at the VA-San Diego.

1 R01 GM085072-01 NIH/NIGMS

Schmid-Schönbein (PI) 5/01/09-04/31/13

Role: Co-investigator

Digestive Enzymes and Microvascular Inflammation in Shock

The aim of this project is to study autodigestion in hemorrhagic shock.

NIH SBIR Phase I Grant

Kistler (Co-PI) 1993

Role: Writer/Originator

Use of Artificial Neural Networks and Advanced Signal Processing Techniques in the Analysis of ECG waveforms

The aim of this project is to use advanced signal processing to automatically detect and diagnose abnormal cardiac rhythms. A Phase II award was subsequently awarded.

Patents:3

Companies Co-founded and Involvement:

Cell Activation, 1998-01, strategies for inflammatory mediator mitigation

Kislace (LLC), 2005-present, ex-vivo diagnostic devices

Original Research Articles:

1. Martinez JB, Aletti F, Pinto BB, Ribas V, Odena MA, Díaz R, Medina ER, Ferrer R, Kistler EB, Tedeschi G, Schmid-Schönbein GW, Herpain A, Bendjelid K, de Oliveira E. “Proteolysis in Septic Shock Patients: Plasma Peptidomic Profile is Associated with Mortality”, BJ Anes. In press, 2018.

2. Mazor R, Friedmann-Morvinski D, Alsaigh T, Kleifeld O, Kistler EB, Rousso-Noori L, Huang C, Li JB, Verma, IM, Schmid-Schönbein GW, “Cleavage of the leptin receptor by matrix metalloproteinase-2 promotes leptin resistance and obesity”, Science Trans. Med. In press, 2018.

3. Braga D, Barcella M, D'Avila F, Lupoli S, Tagliaferri F, Santamaria MH, DeLano FA, Baselli G, Schmid-Schönbein GW, Kistler EB, Aletti F, Barlassina C. Preliminary profiling of blood transcriptome in a rat model of hemorrhagic shock. Exp Biol Med (Maywood). 2017 Aug;242(14):1462-1470. PMID: 28661205

4. Santamaria M, Aletti F, Li JB, Tan A, Chang M, Leon J, Schmid-Schönbein GW, Kistler EB. Enteral tranexamic acid attenuates vasopressor resistance and changes in α1-adrenergic receptor expression in hemorrhagic shock. J Trauma Acute Care Surg. 2017 Aug;83(2):263-270. PMID: 28422915.

5. Nguyen AP, Gabriel RA, Golts E, Kistler EB, Schmidt U. Severity of acute kidney injury in the post-lung transplant patient is associated with higher health care resources and costJ Cardiothorac Vasc Anesth. 2017 Aug;31(4):1361-1369. PMID:28455097.

6. Aletti F, Maffioli E, Negri A, Santamaria MH, DeLano FA, Kistler EB, Schmid-Schönbein GW, Tedeschi G. Peptidomic analysis of rat plasma: proteolysis in hemorrhagic shock. Shock.2016 May;45(5):540-54. PMID: 26863123

7. Maffioli E, Aletti F, Santagata F, Negri A, Santamaria MH, DeLano FA, Kistler EB, Schmid-Schönbein GW, Tedeschi G. Set up of a protocol for rat plasma peptidomics in hemorrhagic shock model in presence of heparin. EuPA Open Proteomics2016 February;12:1-3. DOI: 10.1016/j.euprot.2016.03.004

8. Alsaigh T, Chang M, Richter M, Mazor R, Kistler EB. In vivo analysis of intestinal permeability following hemorrhagic shock. World J Crit Care Med. 2015 Nov 4;4(4):287-95. doi: 10.5492/wjccm.v4.i4.287. PMID: 26557479

9. Cohen-Mazor M, Mazor R, Kristal B, Kistler EB, Ziv I, Chezar J, Shifra S. Heparin interaction with the primed polymorphonuclear leukocyte CD11b induces apoptosis and prevents cell activation. J Immunol Res. 2015:751014. PMID: 26819958

10. Tsai AG, Salazar-Vázquez BY, Cabrales P, Kistler EB, Tartakovsky DM, Subramaniam S, Acharya SA, Intaglietta M. Replacing the transfusion of 1-2 units of blood with plasma expanders that increase oxygen delivery capacity. JFunc Biomaterials. 2014 Oct 27;5(4):232-45. PMID: 25350267

11. Mazor R, Alsaigh T, Shaked H, Altshuler AE, Pocock ES, Kistler EB, Karin M, Schmid-Schönbein GW. Matrix metalloproteinase-1-mediated up-regulation of vascular endothelial growth factor-2 in endothelial cells. J Biol Chem. 2013 Jan 4;288(1):598-607. PMID: 23155052

12. Kistler EB, Alsaigh T, Chang M, Schmid-Schönbein GW. Impaired small-bowel barrier integrity in the presence of lumenal pancreatic digestive enzymes leads to circulatory shock. Shock. 2012 Aug;38(3):262-7. PMID: 22576000[Cover, featured article].

13. Chang M, Alsaigh T, Kistler EB, Schmid-Schönbein GW. Breakdown of mucin as barrier to digestive enzymes in the ischemic rat small intestine. PLoS One. 2012;7(6):e40087. PMID: 22768227

14. Chang M, Kistler EB, Schmid-Schönbein GW. Disruption of the mucosal barrier during gut ischemia allows entry of digestive enzymes into the intestinal wall. Shock. 2012 Mar;37(3):297-305. PMID: 22089198

15. Schmid-Schonbein GW, DeLano FA, Penn AH, Kistler E. An elementary analysis of physiologic shock and multi-organ failure: the autodigestion hypothesis. Conf Proc IEEE Eng Med Biol Soc. 2012:3114-5. PMID: 23366584

16. Mitsuoka H, Kistler EB, Schmid-Schönbein GW. Protease inhibition in the intestinal lumen: attenuation of systemic inflammation and early indicators of multiple organ failure in shock. Shock. 2002 Mar;17(3):205-9. PMID: 11900339

17. Schmid-Schönbein GW, Kistler EB, Hugli TE. Mechanisms for cell activation and its consequences for biorheology and microcirculation: Multi-organ failure in shock. Biorheology. 2001;38(2-3):185-201. PMID: 11381174

18. Kistler EB, Lefer AM, Hugli TE, Schmid-Schönbein GW. Plasma activation during splanchnic arterial occlusion shock. Shock. 2000 Jul;14(1):30-4. PMID: 10909890

19. Kistler EB, Hugli TE, Schmid-Schönbein GW. The pancreas as a source of cardiovascular cell activating factors. Microcirculation. 2000 Jun;7(3):183-92. PMID: 10901497

20. Mitsuoka H, Kistler EB, Schmid-Schonbein GW. Generation of in vivo activating factors in the ischemic intestine by pancreatic enzymes. Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1772-7. PMID: 10677533

Review Articles

21. Altshuler A, Kistler EB, Schmid-Schönbein GW. Autodigestion: Proteolytic degradation and organ failure in shock. Shock. 2016 May;45(5):483-9. PMID: 26717111

22. Dhillon A, Nguyen J, Kistler E. Sepsis: a review of therapeutics and considerations for anesthesiologists. Am J Ther. 2012 Nov;19(6):e167-71. Review. PMID: 21317624

23. Schmid-Schönbein GW, Penn A, Kistler E. The Autodigestion Hypothesis in Shock and Multi-Organ Failure: Degrading Protease Activity. Bol Soc Port Hemorreol Microcirc. 2011 Jul;26(3):6-15. PMID: 25284955

24. Bigatello LM, Kistler EB, Noto A. Limitations of volumetric indices obtained by trans-thoracic thermodilution. Minerva Anestesiol. 2010 Nov;76(11):945-9. Review. PMID: 21102390

25. Bigatello LM, Kistler EB, Noto A. Authors’ Reply: Limitations of volumetric indices obtained by transthoracic thermodilution. Minerva Anestesiol. 2011 Jul;77(7):756-7.

26. Schmid-Schönbein GW, Hugli TE, Kistler EB, Sofianos A, Mitsuoka H. Pancreatic enzymes and microvascular cell activation in multiorgan failure. Microcirculation. 2001 Feb;8(1):5-14. Review. PMID: 11296853

Book Chapters

27. Kistler, EB,Lecture 18: Renal function, fluid and electrolyte balance and intraoperative fluid therapy”, Audio-Digest Anesthesiology, 5th Edition, 2018.

28. Kistler, EB, “Lecture 15. Intra-operative Fluid Therapy”, Audio-Digest Anesthesiology, 2ndEdition, 2015.

29. Kistler EB, “Optimizing the Bowel/Difficult Airway”, Audio-Digest Anesthesiology, Vol 56, #6, 2014 ISSN: 0271-1265.

30. Kistler EB, “Chapter 2-2 Cardiac Rhythm Disturbances”, The MGH Review of Critical Care Medicine, 1st edition, Berg S, editor, Wolters Kluwer Health, 2013.

31. Kistler EB, Benumof J, “The Difficult Airway”, Manual of Clinical Problems in Pulmonary Medicine, Seventh edition, Morris T, Ries A, and Bordow R, editors, Lippincott Williams & Wilkins, 2013.

32. Kistler EB, Bigatello LM, “Chapter 1: Hemodynamic Monitoring” in Critical Care Handbook of the Massachusetts General Hospital, Fifth edition, Lippincott Williams & Wilkins, 2009.

33. Penn AH, Kistler EB, Schmid-Schönbein GW, “Bioengineering of Inflammation and Cell Activation: Autodigestion in Shock”, Bioengineering in Cell and Tissue Research, Artman, GM, and Chien, S, editors, Springer (Paris) 2008, pp 509-526.

34. Cain, JG, Cohen JB,Kistler EB,Camporesi EM, “Chapter 60: Shock”, Trauma: Resuscitation, Anesthesia, and Critical Care, Wilson WC, Grande CM, and Hoyt DB, editors, Informa Healthcare, USA (NY), 2007.

35. Fitzal F,Kistler EB, Mitsuoka H, Hugli TE, Schmid-Schönbein GW, “A new hypothesis for the origin of shock: Self-digestion of the ischemic intestine by pancreatic enzymes” Progress in Inflammation, Pitzer JA, editor, Nova Science Pub., 2005.

36. Schmid-Schönbein GW, Hugli TE, Mitsuoka H, Kistler EB,“Mechanisms for Microvascular Cell Activation: Pancreatic Digestive Enzyme Derived Inflammatory Mediators in Shock” Molecular Basis for Microcirculatory Disorders, December 2002, pp.255-268, DOI: 10.1007/978-2-8178-0761-4_12

37. Schmid-Schönbein GW, Hugli TE, Mitsuoka H, Kistler EB, “Microvascular cell activation and pancreatic enzyme derived inflammatory mediators”,The Molecular Basis of Microcirculatory Disturbances, Schmid-Schönbein GW and Granger DN, editors, Springer (Paris), 2002.

38. Kistler EB, Ph.D. Dissertation (UC San Diego): Humoral Mechanisms of Cellular Activation in Ischemic Shock, (UMI, Ann Arbor, MI), 1998.

Abstracts and National/International Invited Presentations:

1. Kistler EB, Schmid-Schönbein GW, “Autodigestion: a missing link for biomechanical analysis of cardiovascular disease states”, presented at the World Congress for Biomechanics, Dublin, Ireland, 2018.

2. Kistler EB, “Protecting the gut”, presented at the Society for Cardiovascular Anesthesiologists, Phoenix, AZ, 2018.

3. Aletti F, Bauzà Martinez J, Bollen Pinto B, Herpain A, Schmid-Schönbein GW,Baselli G, Ferrer R, Bendjelid K, de Oliveira E, Kistler EB, “Gut-derived peptides in the blood of patients in septic shock”, presented at the Shock Society Conference, Phoenix, AZ, 2018.

4. Maffioli E, Aletti F, Grassi Scalvini F, Nonnis S, Santagata F, Morelli S, Kistler EB, Schmid-Schönbein GW, Negri A, Tedeschi G, “Peptidomic characterization of hemorrhagic shock plasma samples: effects of tranexamic acid”, presented at theInternational Conference on Complex Acute Illness (ICCAI), Milan, Italy, 2017.

5. Schmid-Schönbein, GW, Kistler EB, “Autodigestion: A source of cell dysfunction and multiorgan failure”, presented at the Biomarker Summit, San Diego CA, 2017.

6. Kistler EB, Aletti F, DeLano FA, Schmid-Schönbein GW, “Autodigestion as mechanism for multi-organ failure in shock”, J Crit Care,42:379-380, 2017.

7. Aletti F, Tan A, Mu H, Trieu D, Schmid-Schönbein GW, DeLano FA, Kistler EB, “Prevention of intestinal damage by continuous minimally invasive enteral infusion of protease inhibitor in hemorrhagic shock”, presented at the Shock Society Conference, San Antonio, TX, 2017.

8. Aletti F, DeLano FA, Kistler EB, “Enteral Protease Inhibition in Trauma/Hemorrhagic Shock: Effects on Biochemical Parameters”, presented at theSociety of Critical Care Medicine,Honolulu, Honolulu, HI, 2017.

9. Schmid-Schönbein GW, Mazur R, Kistler EB, “Autodigestion and Proteolytic Receptor Cleavage as Basis for Cell Dysfunction and Organ Failure” presented at the Biomedical Engineering Society Conference, San Diego, CA, 2017.

10. Kistler EB, Li J, Munoz DC, Mazor R, Santamaria M, “ACE Inhibition by Circulating Peptides Formed De-Novo in Experimental Hemorrhagic Shock”, presented at theSociety of Critical Care Medicine,Honolulu, HI, 2017.

11. Aletti F, Penn AH, Kistler EB, Ferrario M, “Merging physiological and statistical models for a better understanding of shock”, presented at theInternational Conference on Complex Acute Illness (ICCAI), Pasadena, CA, 2016.

12. Nguyen A, Webb T, Kistler E. “791: Retrospective analysis of lengthy stays in a surgical ICU”, Crit Care Med. 2015 Dec;43(12 Suppl 1):199. PMID: 26570452.

13. Webb TT, Wailes DH, Nguyen AP, Kistler EB, “Retrospective analysis of lengthy stays in a surgical ICU”, presented at the Western Anesthesiology Resident Conference (WARC), Seattle, WA, 2015.

14. Schmid-Schönbein GW, DeLano FA, Santamaria MA, Aletti F, Kistler EB, Penn AH, Altshuler AE, “The Autodigestion Hypothesis for Organ Failure in Shock”, presented at the World Conference on the Microcirculation, Kyoto, Japan, 2015.

15. Santamaria M, Aletti F, DeLano FA, Kistler EB, Schmid-Schönbein GW, “Effect of digestive enzyme inhibition in the intestine on protease levels in the plasma in hemorrhagic shock”, presented at the Biomedical Engineering Society Conference, Tampa, FL, 2015.

16. Maffioli E, Aletti F, Nonnis S, Santagata F, Negri A, DeLano FA, Santamaria MH, Kistler EB, Schmid-Schönbein GW, Tedeschi G, “HEM-6: Analysis of rat plasma peptidome in hemorrhagic shock”. Shock. 2015 Oct;44 Suppl 2:2-3. doi: 10.1097/01.shk.0000472010.12988.4f. PMID: 26375068

17. Aletti F, Santamaria MH, DeLano FA, Schmid-Schoenbein GW, Kistler EB, “HEM-5: Transmembrane receptor density in the heart under hemorrhagic shock”. Shock. 2015 Oct;44 Suppl 2:2. doi: 10.1097/01.shk.0000472009.12988.99. PMID: 26375067

18. Santamaria M, AlettiF, Chin, K, DeLano FA, Schmid-Schönbein GW, Kistler EB, “Enteral blockade of digestive proteases attenuates vasopressor resistance after hemorrhagic shock”, presented at the Shock Society Conference, Denver, CO, 2015.

19. Kistler EB, Schmid-Schönbein GW, “Autodigestion and its manifestations in the microcirculation” presented at the 2015 Summer Biomechanics, Bioengineering and Biotransport Conference (SB3C2015), Snowbird, UT, 2015.

20. Kistler EB, “The role of the bowel in shock and critical illness” (Invited Plenary Lecture) presented at the 53d Annual Weil/UCSD Symposium on Critical Care and Emergency Medicine, Las Vegas, NV, 2015.

21. Kistler EB, “Optimizing oxygen delivery in the microcirculation / Implications for blood transfusion” (Invited Plenary Lecture) presented at the 53d Annual Weil/UCSD Symposium on Critical Care and Emergency Medicine, Las Vegas, NV, 2015.

22. Nguyen AP, Harlan EE, Kistler EB, “Long-term outcomes in a surgical ICU (revised)”, presented at the Society of Critical Care Medicine Conference, Phoenix, 2015.

23. Nguyen AP, Harlan EE, Kistler EB, “Long-term outcomes in a surgical ICU”, presented at the Western Anesthesiology Resident Conference (WARC), Los Angeles, CA, 2014.

24. Kistler EB, “The role of digestive enzymes in circulatory shock”, SOCCA-FAER-Hospira Physician Scientist Award Lecture, presented at the Society of Critical Care Anesthesiologists (SCCA), San Francisco, CA, 2013.

25. Kistler EB, Altshuler AE, DeLano FA, Penn AA, Schmid-Schönbein GW, “The autodigestion hypothesis for circulatory shock: Digestive enzymes in the microcirculation”, (Invited Plenary Lecture) presented at the International Conference for Microcirculation, Beijing, China, 2013.

26. Kistler EB, “Shock and multiorgan failure: biomechanical mechanisms to prevent autodigestion” (Invited Plenary Lecture) presented at the American Society of Mechanical Engineers (ASME) International Congress & Exposition, San Diego, CA, 2013.

27. Mody NS, Chou HG, Minokadeh A, O’Brien EO, Newhouse B,Kistler E, Robbins K, Pretorius V, Copeland J, Wilson WC, “Statin and amiodarone associated rhabdomyolysis in an LVAD patient: Role of TTE”, presented at the Western Anesthesiology Resident Conference (WARC), Albuquerque, NM, 2013.

28. Chou HG, Gerstein N, Smith EA, Mody NS, O’Brien EO, Newhouse B, Kistler EB, Robbins K, Minokadeh A, Pretorius V, Copeland J, Wilson WC, “Postpartum coronary dissection: from TandemHeart to HeartMate II”, presented at the Western Anesthesiology Resident Conference (WARC), Albuquerque, NM, 2013. 1st Prize Winner for Cardiovascular Anesthesia.

29. Chou HG, Gerstein N, Smith EA, Mody NS, O’Brien EO, Newhouse B, Kistler EB, Robbins K, Minokadeh A, Pretorius V, Copeland J, Wilson WC, “Pandrug resistant pseudomonas aeruginosa ventricular assist device associated Infection”, presented at the Western Anesthesia Residents Conference, Albuquerque, NM, 2013.

30. Kistler EB, “Therapy should be targeted to markers of tissue perfusion”, (Invited Lecture) presented at the 3d Goal-Directed Therapy Symposium, Newport Beach, CA, 2013.

31. Kistler EB, “Single dose enteral tranexamic acid for the reduction of morbidity in hospitalized critically ill patients; A Phase II-type trial”, (Invited Lecture) presented at the14th University of California Systemwide Bioengineering Symposium, San Diego, CA, 2013.

32. Kistler EB, Alsaigh T, Hugli TE, Schmid-Schönbein GW, “Mechanisms of bowel-mediated hypotension from pancreatic-derived peptides”, presented at the Shock Society Conference, San Diego, CA, 2013.

33. Kistler EB, Alsaigh T, Hugli TE, Schmid-Schönbein GW, “Biological activity of isolated inflammatory peptides from the pancreas and their possible role in shock”, presented at the Shock Society Conference, Miami Beach, FL, 2012.

34. Kistler EB,Alsaigh T, Richter , Chang M, Schmid-Schönbein GW, “Proteolytically-derived inflammatory peptides from the bowel may circulate systemically in shock”, presented at Experimental Biology, San Diego, CA, 2012.

35. Chang, M, Alsaigh T, Kistler EB, Schmid-Schönbein GW, Mucin protects against trypsin-mediated increases in intestinal epithelial permeability”, presented at Experimental Biology, San Diego, CA, 2012.

36. Kistler EB, Alsaigh T, Hugli TE, Schmid-Schönbein GW, “Small bowel permeability increases in hemorrhagic shock: a possible role for pancreatic-derived inflammatory peptides”, presented at the Society of Critical Care Medicine Conference, Houston, TX, 2012.

37. Kistler EB, Alsaigh T, Hugli TE, Schmid-Schönbein GW, “Isolation of inflammatory peptides as products of digestive enzymes in the pancreas”, presented at the Shock Society Conference, Norfolk, VA, 2011.

38. Chang, M., Kistler EB, Schmid-Schönbein GW, “Digestive degradation of intestinal mucin during splanchnic ischemia”, presented at the Microcirculatory Conference (FASEB) Washington, DC, 2011.

39. Kistler EB, Alsaigh T, Schmid-Schönbein GW, “The role of pancreatic digestive enzymes in an experimental model of gut-derived circulatory shock”, presented at the 4thWorld Congress of Microcirculation, Paris, France, 2010.

40. Kistler EB, Alsaigh T, Schmid-Schönbein GW, “Compromise of intestinal wall in the presence of pancreatic enzymes causes circulatory shock”, presented at the Shock Society Conference, Portland, OR, 2010.

41. Kistler EB, Bigatello LM, “A critical analysis of end-diastolic and extravascular lung water volumes as determined by the PiCCO cardiovascular monitor,” presented at the Society of Critical Care Medicine Conference, Miami, FL, 2010.

42. Kistler EB,Schmid-Schönbein GW, “Gut wall compromise in the presence of pancreatic enzymes causes circulatory shock”, (Selected for Special Presentation), presented at the Microcirculatory Conference (FASEB), Anaheim, CA, 2010.

43. Kistler EB, Schmid-Schönbein GW, “Intralumenal protease inhibition in hemorrhagic shock”, presented at the Western Anesthesia Residents Conference, Sacramento, CA, 2007.

44. Schimmeyer, SM, Kistler EB, Schmid-Schönbein GW, “Intralumenal protease inhibition in splanchnic arterial occlusion shock”, (semifinalist) presented at the Western Anesthesia Residents Conference, Snowbird, UT, 2006.

45. Schmid-Schönbein GW, Kistler EB, Mitsuoka H, Hugli TE, “Mechanisms for cell activation in the cardiovascular system during physiological shock”, presented at the 4th World Conference on Biomechanics, Calgary, Canada, 2002.

46. Schmid-Schönbein GW, Kistler EB, Mitsuoka HM, Hugli TE, “The obligatory role of pancreatic enzymes in cardiovascular cell activation: a mechanism for multiorgan failure”, presented at the Biomedical Engineering Society Conference, Big Sky, MO, 2001.

47. Mitsuoka H, Kistler EB, Schmid-Schönbein GW, “Production of activating factors in the ischemic intestine by pancreatic enzymes”, FASEB J, 14(4): A16, 2000.

48. Kistler EB, Sofianos A, Hugli TE, Schmid-Schönbein GW, “Cardiovascular activating factors from the pancreas”, presented at the First Joint Meeting of the Biomedical Engineering Society and Engineering in Medicine and Biology Society (IEEE) Conference, Atlanta, GA, 1999.

49. Mitsuoka H, Kistler EB, Schmid-Schönbein GW, “Inhibition of intestinal proteases decreases cellular activation in SAO shock”, presented at the First Joint Meeting of the Biomedical Engineering Society and Engineering in Medicine and Biology Society (IEEE) Conference, Atlanta, GA, 1999.

50. Kistler EB,Mitsuoka H, Hugli TE, Schmid-Schönbein GW, “Pancreatic neutrophil activators in SAO shock”, Shock, 11(Supplement): 9, 1999.

51. Mitsuoka, H., Kistler EB, Schmid-Schönbein GW, “Intestinal lavage increases survival after intestinal shock”, Shock, 11(Supplement): 9, 1999.

52. Kistler EB, Hugli TE, Schmid-Schönbein GW, “In vivo inflammatory response to pancreatic activators”, FASEB J, 13(5): A19, 1999.

53. Kistler EB, Sofianos A, Hugli TE, Schmid-Schönbein GW, “A partial characterization of neutrophil activating factors from porcine pancreas”, FASEB J, 13(5): A758, 1999.

54. Kistler EB, Hugli TE, Schmid-Schönbein GW, “Serine proteases may produce neutrophil activators from several internal organs” presented at the Conference for Experimental Biology, San Francisco, CA, 1998.

55. Kistler EB, Lefer AM, DeLano FA, Pfeifer P, Hugli TE, Zweifach BW, Schmid-Schönbein GW, “Endogenous sources of plasma activation in the rat”, Microcirculation, 4(1): 130, 1997.

56. Kistler EB, Lacy F, Suzuki R, Lefer AM, Zweifach BW, Schmid-Schönbein GW, “In vitro chemiluminescence measurements of plasma superoxide production by pancreatic activating factor(s)”,Annals of Biomedical Engineering, 25(Supplement 1): S-56, 1997.

57. Kistler EB, Brondeau A, Pfeifer P, Lefer AM, Zweifach BW, Schmid-Schönbein GW, “In vitro neutrophil activating factors present in porcine pancreas”,Annals of Biomedical Engineering, 25(Supplement 1): S-56, 1997.

58. Lacy F, Kistler EB, Lee MM, Gough DA, Zweifach BW, Schmid-Schönbein GW, “Oxygen free radical measurements in blood plasma”, Microcirculation, 4(1): 176, 1997.

59. Kistler EB, Lefer AM, DeLano FA, Zweifach BW, Schmid-Schönbein GW, “Splanchnic arterial occlusion shock and plasma activation in the rat”, Intl J Microcirculation, 16(Supplement 1): 202, 1996.

60. Wiederhold, MD, Kistler EB, Brotherton T, “Categorization of degree carotid arterial stenosis using artificial neural networks and advanced signal processing techniques”, presented at the American Society for Ultrasound in Medicine Conference, Honolulu, HI, 1993.

Presentations and Invited Lectures:

“Optimizing the bowel: in the OR and ICU”, Grand Rounds, Department of Anesthesiology, University of West Virginia (6/2014)

“The bowel and its role in the acute inflammatory response”, Combined Critical Care Lecture Series, UC San Diego (4/2014)

“Postoperative care of the surgical patient”, Fellows Lecture, Division of Pulmonary Medicine, Dept of Medicine, UC San Diego (6/2013)

“Single dose enteral tranexamic acid for critically ill patients: an update on the clinical trial”, Scholarly Activities Meeting (SAM), Division of Pulmonary Medicine, Dept of Medicine, UC San Diego (5/2013)

“Shock and pressors”, Fellows Lecture, Division of Pulmonary Medicine, Dept of Medicine, UC San Diego (5/2013)

“Single dose enteral tranexamic acid for critically ill patients”, Scholarly Activities Meeting (SAM), Division of Pulmonary Medicine, Dept of Medicine, UC San Diego (7/2012)

“PACU care in the ICU”, Thornton ICU nursing, UC San Diego (10/2012)

“Post-operative sedation and analgesia: perspectives from the ICU”, Dept of Anesthesia Update Conference, San Diego, CA (1/2010)

“ARDS and vasopressors in sepsis: implications for the OR”, Dept of Anesthesia Update Conference, San Diego, CA (1/2009)

“The PiCCO cardiovascular monitor”, MGH Combined Grand Rounds Depts of Anesthesia Critical Care and Pulmonary Critical Care (2/2008)

“Some thoughts on regional anesthesia and the parturient”, UCSD Dept of Obstetrics and Gynecology (6/2006)

“Cellular origins of shock and the possible role of the gut”, UCSD Dept of Bioengineering (11/1999)

Professional Societies and Service:

Committee member: VA San Diego Critical Care Committee (2017-present)

Committee member: VA San Diego Strategic Analytics for Improvement and Learning (SAIL) Avoidable Adverse Events Team (2018-present)

Committee member: VA San Diego Health Care System, Code Blue Committee (2017-present)

Committee member: Scientific Review Committee, Society of Critical Care Medicine (2015-present)

Committee member: Graduate and Resident Education Committee, Society of Critical Care Medicine (2010-2013)

Committee member (alternate): VA San Diego Health Care System, Research Review Committee (2009-2012)

Committee member: San Diego Patient Safety Council (ICU Sedation Task Force 2009-11)

Committee member: UCSD Dept of Anesthesiology & Critical Care Ad hoc Committee on Promotions (2010-2014)

Council Member, Specialty Committee of Qi-Blood, World Federation of Chinese Medicine Societies (2014-2018)

UC San Diego School of Medicine, Surgery 401 Procedural Skills Lab (2016-present)

External International Advisory Board (EIAB), ShockOmics, European Union (Milan, Italy) (2016-2017)

Professional Societies Member: Shock Society, American Society of Anesthesiologists, Society of Critical Care Medicine, Society of Critical Care Anesthesiologists

Judge, UC San Diego Jacobs School of Engineering, Research Expo Poster Competition (2012-present)

Judge, Western Anesthesiology Residents Conference, Research Poster Competition (2013-2015)

International Anesthesiology Research Society (IARS) Mentored Research Awards (IMRA) Study Section Reviewer (2013-2015)

Department of Defense Study, US Army Medical Research and Materiel Command Extramural Research Section Reviewer (2017-present)

American Thoracic Society Resident “Boot Camp”, “Airway 101” and “Difficult Airway” Instructor (2014)

UCSD Dept of Anesthesiology, Mock Oral Exams, Examiner, 2010-present

UCSD Physician Assessment and Clinical Education (PACE) program examiner, 2014-present

Contributor to Self-Assessment in Adult Multiprofessional Critical Care, 8thEdition, Zanotti-Cavazzoni SL, Pino R. (2017).

Johns Hopkins Center for Talented Youth, Instructor, 1998.

Reviewer: Journal of Respiratory Care, Journal of Clinical Anesthesia, American Journal of Critical Care, Science Translation (ad hoc), BioMed Central Anesthesiology, Anesthesiology (2012-2016), Anesthesia & Analgesia, Comprehensive Physiology

Instruction Experience:

Instructor: Anes 296 Independent Study/Research Elective (3 credits/quarter), Medical Student Asimina Courelli (2017-present)

Post-Doctoral Advisor (2017-present) Fernando Dos Santos, PhD

Post-Doctoral Advisor (2012-present) Rafi Mazor, PhD

Post-Doctoral Advisor (2012-present) Federico Aletti, PhD

Undergraduate Advisor (2015-present) Joyce Li

Doctoral Dissertation Committee Advisor for Augusta Modestino (2013-2015)

Graduate Student Advisor (2013-2015) Derek Tran

Graduate Student Advisor (2013-2016) Marco Santamaria-Aviles

Graduate Student Advisor (2004-2005) Suzanne Schimmeyer, MS, Thesis: “Protease Inhibition Versus Phospholipase A2 Inhibition in Splanchnic Arterial Occlusion Shock”

Advisor for Tom Alsaigh, M.D. (2011-2012)

Graduate Student Advisor (1998-1999) Anastasia Sofianos, MS, Thesis: “Methods for Purification and Partial Characterization of Low Molecular Weight Chemoattractants from Pancreatic Homogenate”

Interests:

Music - piano (classical, rock, jazz), guitar, bass, composition

Languages - French, basic Italian, ‘medical’ Spanish

Sports - Surfing, running, soccer